Stage2 vs stage3 and stage2 vs stage4 | |
---|---|
Gene | Function |
SATB1 | promotes the cell growth |
 | and reduces apoptosis |
BNIP3 | is involved in mTOR signaling |
 | (resulting in increased |
 | protein translation) |
EDNRB | (a transactivator of EGFR) |
 | induces tumor growth |
AQP3 | facilitate colorectal carcinoma |
 | cell migration [44] |
LGR5 | Its expression is significantly |
 | higher in carcinoma than in |
 | normal mucosa [45] |
SCRN1 | associate to a poor prognosis [46] |
Stage2 vs stage3 | |
Gene | Function |
AREG and GRB14 | promote proliferation and |
 | interact with EGFR |
BAMBI | It is involved in TGF-beta |
 | receptor signaling pathway |
 | (growth induction), |
FZD7 | participates to the WNT |
 | signaling pathway |
IRS1 and IRS2 | They are activated by insulin |
PTPRR | It is activated from the MAPK |
 | signaling pathway |
Stage3 vs stage4 | |
Gene | Function |
EREG | which promotes proliferation |
 | and interacts with EGFR |
IGF2 | It is involved in TGF-beta |
 | receptor signaling pathway |
 | (growth induction), |
TFF1 and TTF3 | the growth factors |
BMP7 and SMAD9 | involved in BMP receptor |
 | signaling genes involved in BMP |
 | receptor signaling |
GDF15 and ID1 | growth factors involved in the |
 | TGF-beta signaling pathway |